Later On

A blog written for those whose interests more or less match mine.

And even more: 3000 IU vitamin D daily?

with 5 comments

Take a look at this:

Advances in Vitamin D nutritional physiology since publication of the DRIs in 1997 are briefly summarized. Available data indicate that (1) Vitamin D’s canonical function, optimizing intestinal calcium absorption, is fully expressed at serum 25-hydroxyvitamin D (25OHD) concentration of not, vert, similar80 nmol/L; (2) elevated parathyroid activity, typical of aging populations, is minimized at the same 25OHD value and (3) osteoporotic fractures are reduced when serum 25OHD is raised to near 80 nmol/L. Depending upon starting value, achieving 25OHD concentrations of 80 or higher may require a daily oral intake of 2200 IU (55 μg) or more in addition to prevailing cutaneous inputs. The tolerable upper intake level (TUIL), currently set at 2000 IU (50 μg)/day, is too low to permit optimization of Vitamin D status in the general population. Actual toxicity is not seen below serum 25OHD values of 250 nmol/L, a value that would be produced only at continuing oral intakes in excess of 10,000 IU (250 μg)/day.

I’m increasing my vitamin D supplement to 3000 IU daily.

And, as noted here:

Vitamin D toxicity, when it occurs, is a serious problem. The first sign is a rise in the ratio of calcium to creatinine in the urine, which precedes hypercalcemia and the problems associated with it. Yet, vitamin D toxicity is rare; its risk has been greatly exaggerated by inappropriate animal studies involving pharmacologic doses of vitamin D that have no relevance to human physiology. Heaney and associates gave people 10 000 IU of vitamin D3 daily for 5 months and did not observe a single adverse urinary calcium–creatinine event.

Written by LeisureGuy

21 November 2007 at 9:40 am

Posted in Health, Science

5 Responses

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  1. As I see you live in Monterrey I am sure this amount of vitamin D will be more than adequate but not sufficient to cause trouble. However people should be aware that Monterrey appears to enjoy somewhat more sunshine than the average and being just under the 37N latitude line it should be possible to obtain Vitamin D3 producing UVB rays at ground level for most of the year so the drop in status that usually occurs December-January should be minimal.

    Bruce Hollis who lives/work in Charleston (lat 32) and has spent his working life studying vitamin says ” I try to keep my own level at 125 nmol minimum and consume between 2,000-8,000 IU/day depending on the season”.

    Risk Assessment for Vitamin D is a study that shows amounts under 10,000iu/daily are safe as it takes 40,000iu daily to cause trouble.

    I’m concerned who live further North that people who live much further north that you do may think 3000iu is generally adequate.

    As each 400iu/daily of Vitamin D3 Cholecalciferol only raises status by 9nmol/l 3.6ng/ml 4000iu will produce a rise of 90nmol/l or 36ng/ml

    For people in the UK latitude 52 with an annual sunshine total of 1500hrs this will just about be sufficient to raise status from the average 40nmol/l to 130nmol/l however for those who are housebound or elderly or obese it still won’t be sufficient.

    Most elderly people here have levels around 23nmol/l so 3000iu/daily/D3 is not really going to be sufficient. Though of course for someone at latitude 36 getting above average sunshine for most months of the year 3000iu/d should be fine.

    Edward Hutchinson

    21 November 2007 at 1:51 pm

  2. What dosage 3000 IU relates to, say, 1 tsp?

    Max James

    20 April 2010 at 11:31 pm

  3. It depends on what you’re taking. The dosage should be noted on the container.

    LeisureGuy

    21 April 2010 at 7:17 am

  4. I need to take 3,000 iu of D. I cannot contact 911drugstore by email. Need address of site to purchased this
    item. Can you help?

    fred

    13 July 2010 at 2:49 pm


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