Later On

A blog written for those whose interests more or less match mine.

How to kill herpes

with 7 comments

The article specifically discusses herpes simplex virus 1, which causes cold sores, but it might offer a way to treat herpes simplex virus 2 (genital herpes) and the chicken pox virus.

Now that Duke University Medical Center scientists have figured out how the virus that causes cold sores hides out, they may have a way to wake it up and kill it. Cold sores, painful, unsightly blemishes around the mouth, have so far evaded a cure or even prevention. They’re known to be caused by the herpes simplex virus 1 (HSV1), which lies dormant in the trigeminal nerve of the face until triggered to reawaken by excessive sunlight, fever, or other stresses.

“We have provided a molecular understanding of how HSV1 hides and then switches back and forth between the latent (hidden) and active phases,” said Bryan Cullen, Duke professor of molecular genetics and microbiology.

His group’s findings, published in Nature, also provide a framework for studying other latent viruses, such as the chicken pox virus, which can return later in life as a case of shingles, and herpes simplex 2 virus, a genitally transmitted virus that also causes painful sores, Cullen said.

Most of the time, HSV1 lives quietly for years, out of reach of any therapy we have against it. It does not replicate itself during this time and only produces one molecular product, called latency associated transcript RNA or LAT RNA.

“It has always been a mystery what this product, LAT RNA, does,” Cullen said. “Usually viral RNAs exist to make proteins that are of use to the virus, but this LAT RNA is extremely unstable and does not make any proteins.”

In studies of mice, the team showed that the LAT RNA is processed into smaller strands, called microRNAs, that block production of the proteins that make the virus turn on active replication. As long as the supply of microRNAs is sufficient, the virus stays dormant.

After a larger stress, however, the virus starts making more messenger RNA than the supply of microRNAs can block, and protein manufacturing begins again. This tips the balance, and the virus ultimately makes proteins that begin active viral replication.

The new supply of viruses then travels back down the trigeminal nerve, to the site of the initial infection at the mouth. A cold sore always erupts in the same place and is the source of viruses that might infect another person, either from direct contact, or sharing eating utensils or towels, Cullen said.

The approach to curing this nuisance would be a combination therapy, Cullen said. “Inactive virus is completely untouchable by any treatment we have. Unless you activate the virus, you can’t kill it,” he said.

Cullen and his team are testing a new drug designed to very precisely bind to the microRNAs that keep the virus dormant. If it works, the virus would become activated and start replicating.

Once the virus is active, a patient would then take acyclovir, a drug that effectively kills replicating HSV1.

“In principle, you could activate and then kill all of the virus in a patient,” Cullen said. “This would completely cure a person, and you would never get another cold sore.”

He and the team are working with drug development companies in animal trials to begin to answer questions about how to deliver this drug most effectively.

Written by LeisureGuy

3 July 2008 at 9:52 am

Posted in Daily life, Medical, Science

7 Responses

Subscribe to comments with RSS.

  1. This is amazing! I was actually kind of thinking the same thing really. My thoughts were that if the virus hides while in a dormant state, then it would be a matter of making the virus active and then kill it with something… that kills it. :) Great work guys!!! Keep up the testing and please let us know when and if you get it working. I know there is something there. Just need to keep working at it.

    Jason

    19 October 2008 at 5:26 am

  2. Could high doses of the amino acid arginine wake up the virus? Might be something to research.

    Dan

    21 February 2009 at 11:54 pm

  3. I would be so thankful if they actually came up with something like that.

    tom

    27 February 2009 at 6:39 am

  4. My my friend Larry told be about your company and he was also thinking positively about purchasing your product. As matter of fact, by next week he is going place his order but I need to know from your heart with your product kill this monster that I have. Have other people contacted you and said thank you very much for curing them. I know so many people who are depress and they don’t want to continue to be miss lead. Therefore, please tell the truth; does this product truly work. I can wait til Larry buy your product. Email me back with information please. Thank you very much.

    Anonymous

    28 April 2009 at 3:21 pm

  5. The post above is the extent of my knowledge.

    LeisureGuy

    28 April 2009 at 4:16 pm

  6. i jus wanna say thanx for eberything you guys are doing i pray that you all find the cure. im cheering you on. GOD WILL HELP YOU to find it. in our lifetimes. hopefully in the next 3 to 5 years.

    A Person

    6 May 2009 at 8:43 pm

  7. Thank God! I have hope it will be soon. Death to herpes

    tony

    6 April 2010 at 11:30 pm


Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out / Change )

Twitter picture

You are commenting using your Twitter account. Log Out / Change )

Facebook photo

You are commenting using your Facebook account. Log Out / Change )

Google+ photo

You are commenting using your Google+ account. Log Out / Change )

Connecting to %s

Follow

Get every new post delivered to your Inbox.

Join 1,191 other followers