Archive for November 2011
“Death From Above”: A poignant story
The US military actions may not be helping so much as we want to believe. Clive Stafford Smith in the NY Times tells of a meeting in Pakistan and what followed:
LAST Friday, I took part in an unusual meeting in Pakistan’s capital, Islamabad.
The meeting had been organized so that Pashtun tribal elders who lived along the Pakistani-Afghan frontier could meet with Westerners for the first time to offer their perspectives on the shadowy drone war being waged by the Central Intelligence Agency in their region. Twenty men came to air their views; some brought their young sons along to experience this rare interaction with Americans. In all, 60 villagers made the journey.
The meeting was organized as a traditional jirga. In Pashtun culture, a jirga acts as both a parliament and a courtroom: it is the time-honored way in which Pashtuns have tried to establish rules and settle differences amicably with those who they feel have wronged them.
On the night before the meeting, we had a dinner, to break the ice. During the meal, I met a boy named Tariq Aziz. He was 16. As we ate, the stern, bearded faces all around me slowly melted into smiles. Tariq smiled much sooner; he was too young to boast much facial hair, and too young to have learned to hate.
The next day, the jirga lasted several hours. I had a translator, but the gist of each man’s speech was clear. American drones would circle their homes all day before unleashing Hellfire missiles, often in the dark hours between midnight and dawn. Death lurked everywhere around them.
When it was my turn to speak, I mentioned the official American position: that these were precision strikes and no innocent civilian had been killed in 15 months. My comment was met with snorts of derision.
I told the elders that the only way to convince the American people of their suffering was to accumulate physical proof that civilians had been killed. Three of the men, at considerable personal risk, had collected the detritus of half a dozen missiles; they had taken 100 pictures of the carnage.
In one instance, they matched missile fragments with a photograph of a dead child, killed in August 2010 during the C.I.A.’s period of supposed infallibility. This made their grievances much more tangible.
Collecting evidence is a dangerous business. The drones are not the only enemy. The Pakistani military has sealed the area off from journalists, so the truth is hard to come by. One man investigating drone strikes that killed civilians was captured by the Taliban and held for 63 days on suspicion of spying for the United States.
At the end of the day, Tariq stepped forward. He volunteered to gather proof if it would help to protect his family from future harm. We told him to think about it some more before moving forward; if he carried a camera he might attract the hostility of the extremists.
But the militants never had the chance to harm him. On Monday, he was killed by a C.I.A. drone strike, along with his 12-year-old cousin, Waheed Khan. The two of them had been dispatched, with Tariq driving, to pick up their aunt and bring her home to the village of Norak, when their short lives were ended by a Hellfire missile.
My mistake had been . . .
Continue reading. I wonder how what we’re doing in Pakistan will look in another generation.
Comparison shave
A reader asked yesterday for a comparison of the Green Irish Tweed fragrances between the Queen Charlotte Soaps version and the original Creed version. (Creed’s Green Irish Tweed was Cary Grant’s favorite fragrance.) Nothing loath, I set about to satisfy the request.
I also got a couple of new horsehair shaving brushes from GiftsAndCare.com. The one in the photo is the Vie-Long Brown 13071 and I like it. It’s fairly resilient initially, but seemed to soften in the course of the shave and was quite soft for the third pass. It worked extremely well: I got a Creamy Lather with both soaps, but I have to say that the Creed soap is definitely a cut above—not so much for the fragrance, which in both soaps is quite light, but in the lather itself: richer, creamier, and altogether better. Of course, Creed shaving soap sells for almost 6 times as much as the Queen Charlotte version, and I’m not sure I’d go so far as to rate the lather as 6 times better—twice as good, perhaps, or even three times, but in terms of bang for buck, QCS is the winner; for bang alone, Creed, no contest.
I am quite happy with the brush and tomorrow I’ll use the other horsehair brush I got.
The iKon S3S is another case in which the performance multiplier is less than the price multiplier, but that said, in absolute terms this is one of my very best razors. I’m convinced the secret of its smooth, effective, and comfortable shave is the total mass of the razor pushing the blade’s edge through the (well-prepped) beard. Other razors generally are lighter than the S3S’s 4.5 oz. (Weight includes the (Personna 74 tunsten-steel) blade.)
BullgooseShaving.net still has some of the S3S razors. Given the vagaries of the iKon production schedule, I suggest that if you want one, you get it while you can—there are many guys still awaiting the return of the iKon open-comb bulldog razor, certainly one of the most comfortable shavers I own.
Altogether an informative shave. Thanks, Chris, for the suggestion of the GIT comparison.
Oh, cool! Babbage’s Analytical Engine to be built!
Exciting report by John Markoff in the NY Times:
Researchers in Britain are about to embark on a 10-year, multimillion-dollar project to build a computer — but their goal is neither dazzling analytical power nor lightning speed.
Indeed, if they succeed, their machine will have only a tiny fraction of the computing power of today’s microprocessors. It will rely not on software and silicon but on metal gears and a primitive version of the quaint old I.B.M. punch card.
What it may do, though, is answer a question that has tantalized historians for decades: Did an eccentric mathematician named Charles Babbage conceive of the first programmable computer in the 1830s, a hundred years before the idea was put forth in its modern form by Alan Turing?
The machine on the drawing boards at the Science Museum in London is the Babbage Analytical Engine, a room-size mechanical behemoth that its inventor envisioned but never built.
The project follows the successful effort by a group at the museum to replicate a far less complicated Babbage invention: the Difference Engine No. 2, a calculating machine composed of roughly 8,000 mechanical components assembled with a watchmaker’s precision. That project was completed in 1991. . .
Important news for writers
Scrivener 1.0 for Windows has been released. I used the beta quite a bit, working on the weight-loss book. I kept the files in Dropbox and so could work on them from either the MacBook (Scivener is originally a Macintosh program) or Windows: complete file-compatibility, never a hiccough. The working environment it provides is ideal for a writer in many ways. I strongly recommend however—and I mean STRONGLY recommend—that you view the few brief tutorials and don’t try to figure it out on the fly. I say this from what happened to a close friend of mine.
Anway, it’s well worth the $40, as you can see for yourself from the 30-day free trial. (And if you don’t want it, you can just export your files for your word processor—which you normally do anyway, when you’re finished with the writing and ready to move on to formatting: Scrivener has some elementary formatting, but it is mainlly a working document, and it is kept as a bunch of “notes” that… well, go try it.)
From an email:
It’s been a long time coming, but the wait is over – Scrivener 1.0 for Windows is now officially out of beta and available for download and purchase. You can find the product page here:
http://www.literatureandlatte.com/scrivener.php?platform=win
A Scrivener for Windows licence costs a mere $40 (or $35 for students and educators). There’s also a 30-day free trial available. (The trial runs for 30 days of actual use, not calendar days, so were you only to use it twice a week, it would in effect last for fifteen weeks. There are no hoops to jump through to get the trial, either – you can just click on the download link, install it and start using it.)
No one appreciates prolix newsletters from software companies, so I’ll keep this uncharacteristically pithy – I won’t go into a sales pitch because I’m guessing that if you’ve signed up for this newsletter then you already know what Scrivener is and will hopefully still be interested enough to go check it out. If it’s been so long since you signed up that you’ve forgotten, then please do check out the product page linked above, where you’ll find a wealth of information and screenshots. I do, however, have to say that Lee, the Windows developer, has done an amazing job. I first started developing the Mac version nearly eight years ago, for my own writing, and I’m overjoyed to see it shining and sparkling in all its 1.0 glory on the Windows platform. I hope you will be too.
And yet, as proud as we are of Scrivener for Windows, this is just the beginning – there’s lots more to come, with lots of free 1.x updates in the works (we’ll only charge for major updates, such as from 1.x to 2.0).
So – we hope you like it. We hope Scrivener will prove to be your tool of choice for your own writing, and we look forward to seeing some bestsellers make their way out of the Windows version over the next few years just as they have out of the Mac version (not that Scrivener will make you a bestseller, of course, but we do enjoy basking in reflected glory).
Please allow me to thank everyone who has shown such interest in a Windows version of Scrivener, either by signing up to this newsletter or by writing to us, and an especially big thank you to the hundreds of beta testers who have helped us refine the code and fix bugs over the past year.
If you have any questions, please drop us a line on support@literatureandlatte.com or sales@literatureandlatte.com, or visit the lively community forums at http://www.literatureandlatte.com/forum.
Quite a career—and a cure for virus infections?
In Bloomberg BusinessWeek Olga Khanf describes a man who has enjoyed some success:
The July issue of the science journal PLoS One detailed an explosive finding: a drug that creates a kind of viral self-destruct switch. In years to come it could be used to eradicate diseases from HIV to the common cold. “Forget the flu shot,” wrote Men’s Health. “How about a flu cure?”
Even more impressive, the study’s main researcher isn’t a doctor. Todd Rider entered the Massachusetts Institute of Technology in 1986 at age 17 and left nine years later with four degrees, including a PhD in electrical engineering and computer science. He also minored in relativistic quantum field theory and solid state and optical physics. “Once you start on the path of the dark side, you are hooked,” jokes Rider of his obsession with science.
When he finally graduated in 1995, Rider briefly went to work for a biotech startup but returned to MIT two years later to take the position of staff scientist at the Lincoln Laboratory, which is dedicated to using advanced technology for national security. . .
Bento may be what I want
I downloaded the free trial. Now I wish I had stuck with iCal and Mail.
Super shave, great start
Just before I got into the shower, a little jar of Crema 3P pre-shave cream caught my eye, so I rubbed some into my beard and got into the shower. (I’m still loving the Martin de Candre shampoo, BTW.)
At the sink, I started as always with MR GLO, then used the Wee Scot in the wee travel puck of Czech & Speake, with which I’ve had no problems since the first initial stumble: I think perhaps the puck was so small that I failed to sufficiently load the brush. Using the Wee Scot better matches brush to puck, and I had no problem this time.
This is the second use of the Treet carbon-steel uncoated “Black Beauty” blade. I did notice a slightly rough start, but I proceeded and had a terrific shave. The Slant did me proud once more, and after three passes I applied a splash of Alpa 378 (18 more than a complete circle!) to a perfectly shaved face, if I say it myself.
I discarded the Treet, and next up for tomorrow is a comparison of two Green Irish Tweed shaving soaps: Creed and Queen Charlotte. I’ll be using one of the two new horse brushes, along with the iKon S3S.
For some gorgeous photos of that razor, check out this post on the SimplyShaving forum.
Hard work and ethics
At one time, the prevailing ethos was to work hard, show initiative, and be ethical, and it was expected that in time rewards would follow. Now, as Yglesias points out, things are different:
I suppose I agree with Will Wilkinson about the importance of “an ethos of initiative, hard work, and individual responsibility” though I have no real idea why he thinks most progressives are against such an ethos. It strikes me that cultivating such an ethos is sort of integral to making a progressive agenda work. I think back sometimes to the time when I stumbled into a Stockholm Metro station and got the person working the booth to explain what I needed to do to use the city’s bikeshare system. This wasn’t really her job, and the conversation wasn’t in her native language, and obviously no practical harm would have come to her if she’d blown me off but I take it that she took pride in working for Stockholm Metro and had a self-conception as someone who’s a helpful public servant. Any effective public agency from the United States Marine Corps on down is built in pretty profound ways on an ethos of duty and hard work in an even more profound way than things in the for-profit business sector. People who believe in public sector work and public services must believe in the idea of a strong work-ethic.
But if I look at America today, what I see undermining any meaningful notion of work ethic is a kind of run-amok ethic of moneymaking. The old Calvinist idea about money, as I understood it, was that hard work, discipline, and prudence were moral virtues. They were also things that are more likely than not to lead to personal prosperity. So prosperity shouldn’t be stigmatized as ignoble, it should be rather seen as something likely to flow from virtuous behavior. But this equation assumes that morally speaking what matters is the hard work, the discipline, and the prudence. Cutting corners, lying, cheating, or stealing to make a quick buck doesn’t fit the bill. Earning a multi-million dollar salary to deliver below-average performance as the CEO of a firm and then take a multi-million dollar golden parachute when you get sacked doesn’t fit the bill. Spending your days and nights dreaming up smart regulatory arbitrage schemes doesn’t fit the bill. In terms of what it says about your personal virtue, if you’re going to earn your keep identifying and exploiting previously unknown loopholes in the legal framework, you may as well just go out and break the law.
There’s no particular honor and dignity in owning . . .
Short-ribs reward in the oven
Weeks ago I had a hankering for slow-cooked beef short-ribs, but I wanted to continue losing weight so just wrote down what I wanted. Today I went early to Whole Foods, bought 2 lbs of leanish beef short-ribs, and they’re in a 210ºF oven now, where they’ll spend the day. [I decided for no real reason to raise the oven to 215ºF---right at the boiling point so it should simply simmer. But for the first couple of hours it was at 210ºF.]
I first browned them well in a cast-iron skillet while I put into my Dutch oven:
2 handfuls chopped celery
1 large Spanish onion, coarsely chopped
5 slender carrots, chopped
15-20 small pre-peeled garlic cloves, chopped
I nestled the short ribs into the vegetables, squeezed the juice of two regular (non-Meyer) lemons over them, poured over 1/4 c red wine, and added:
good sprinkling thyme
lots of ground pepper
about 1 Tbsp Worcestershire sauce
light sprinkling crushed red pepper
10 mushrooms, cut into thick slices
2 Tbsp horseradish
1-2 tsp Penzeys beef soup base
Very little liquid to begin with, but the onions, mushrooms, and celery will contribute a fair amount as they cook down. It’s a bad mistake to add much liquid at all until the vegetables have had a chance to cook down some.
UPDATE: The veg have thrown off a good amount of liquid. I’m thinking I’ll skim the fat and then immerse egg noodles in the liquid to cook: they will absorb some and be tastier.
Great shave, in the end
I went with The Shave Den’s pre-shave balm again, this time using it as instructed: rubbing it into my beard before the shower, then washing my beard at the sink as usual, using MR GLO. I got quite a nice lather with this Semogue brush—I believe it’s the 610—and the knot really seems to be a brush knot, without the bristle chaos that characterized the other Semogue brushes (the 2000 and the Owner’s Club). But I think the 820 would be better: a longer loft seems to work well with boar.
Still: great lather for the first pass, but the remaining balm did not seem so helpful, making my skin a little grabby. And by the time the first pass was finished, so was the lather in the brush: I had to go work up a new bunch of lather, more or less from scratch. I’m not sure of the cause, but I’m thinking it was the oil of the balm. I may well return to balmlessness.
The iKon H2O asymmetric razor with its Personna 74 tungsten-steel blade did a fine job, despite the lather struggles: three passes produced a wonderfully smooth face, and a little dab of the Saint Charles Shave Avocado aftershave balm was a fine finish.
Brush: meh, but okay. The 820 is a better bet. TSD’s pre-shave balm: I’m going to find another use—it’s good stuff, but with this shave it didn’t help. I’ll try it with a different soap and brush combo.
Sharing successes
A couple:
First, I am now wearing (and have place an order for more) a pair of Rail Rider Back-Country Khakis with 32″ waist—and that’s a comfortable, flat 32″ waist, not the highly-indented, face-purpling 32″ waist. That was a goal when I first started this weight loss, and while I knew it was theoretically possible, I had strong practical doubts. But I’m here, and I’m loving it. And I do like those trousers.
BTW: a) That site doesn’t work with the Chrome browser, and b) they seem to be discontinuing this particular design, so stock up if you like the looks.
Second, a very good batch of pepper sauce:
3 red Anaheim peppers
1 qt jalapeños, and these were spirited, having stretch marks
8 habaneros
12 dried chipotles
1 small can chipotles in adobo
16 cloves garlic
1/3 c Barbados molasses
2 Tbsp olive oil
White vinegar to cover
1/3 c sea salt
Blend; bring to boil and simmer 30 minutes; let cool 30 minutes; blend; bottle.
It made about 1.5 qt.
And I successfully figured out (to my own satisfaction) how Maid in Manhattan was such a flop despite a supporting cast (supporting cast!) of Bob Hoskins, Natasha Richardson, Ralph Fiennes, and Stanley Tucci—and that’s the problem right there: the star they’re supporting with all that high-wattage acting capability is Jennifer Lopez, doubtless a charming woman and able performer, but don’t you sense she might be a bit out of her depth here? The script doesn’t help, because in this sort of situation everything must be turned down so that the star can shine. And if the star’s maximum wattage is slightly less than a living-room lightbulb, that means everything else has to be dimmed to death. And it was.
That aside, things going well. I do wonder why I always recall The (original) Ladykillers as being in black and white, when it was in fact Technicolor. And if you haven’t seen it, you should.
Wicked_Edge just passed 5,000 enrollees or subscribers or registrants or citizens or whatever it is. Members. I’m betting it will pass 6,000 before year’s end, handily.
Bass-ackwards locution
It suddenly struck me that the common expression “If I were you, I’d…” is exactly wrong. The true statement would be, “If you were me, you’d…” because we are exactly saying what we would do in the situation, which may not be at all what you would (or should) do: we’re different, after all. The variability of responses to any given brand of blade proves that. (You knew I’d work shaving in, given a chance, didn’t you?)
UPDATE: Maybe it’s deliberately wrong and the oppoite of the sense, as in the common use of “I could care less” to signify “I could not care less.”
The US oligarchy
Paul Krugman has a good column today:
Inequality is back in the news, largely thanks to Occupy Wall Street, but with an assist from the Congressional Budget Office. And you know what that means: It’s time to roll out the obfuscators!
Anyone who has tracked this issue over time knows what I mean. Whenever growing income disparities threaten to come into focus, a reliable set of defenders tries to bring back the blur. Think tanks put out reports claiming that inequality isn’t really rising, or that it doesn’t matter. Pundits try to put a more benign face on the phenomenon, claiming that it’s not really the wealthy few versus the rest, it’s the educated versus the less educated.
So what you need to know is that all of these claims are basically attempts to obscure the stark reality: We have a society in which money is increasingly concentrated in the hands of a few people, and in which that concentration of income and wealth threatens to make us a democracy in name only.
The budget office laid out some of that stark reality in a recent report, which documented a sharp decline in the share of total income going to lower- and middle-income Americans. We still like to think of ourselves as a middle-class country. But with the bottom 80 percent of households now receiving less than half of total income, that’s a vision increasingly at odds with reality.
In response, the usual suspects have rolled out some familiar arguments: the data are flawed (they aren’t); the rich are an ever-changing group (not so); and so on. The most popular argument right now seems, however, to be the claim that we may not be a middle-class society, but we’re still an upper-middle-class society, in which a broad class of highly educated workers, who have the skills to compete in the modern world, is doing very well.
It’s a nice story, and a lot less disturbing than the picture of a nation in which a much smaller group of rich people is becoming increasingly dominant. But it’s not true. . .
Other people’s shopping carts
Yesterday I arrived at the supermarket checkout behind a man in his 20′s who put on the best:
1 package rigatoni
1 large jar Ragu spaghetti sauce
1 large onion
1 can ripe olives
1 lb ground turkey
I can guess the dinner menu. Only thing missing is 1 bottle chianti, though in fact I’d dress up the Ragu with more than onion:
garlic
celery
parsley
anchovies
crushed red pepper
dash balsamic vinegar
Busy day
Friday is laundry day at chez Ham, and it’s going now. I have to make big new batch of pepper sauce, so I’ll get that started while I do dishes. Lately for some reason I’m craving steak. I’m being sensible about it: I’m buying steaks, cooking them, and eating them. But I pick smaller steaks, and I keep my eye on the weight and don’t go overboard on anything. (BMI this morning: 24.0.)
I use this method of cooking the steak. Works well—last night I cranked the oven to 475ºF.
The result, however, is a collection of dirty cast-iron skillets, etc.
Another project: I want to start tracking my spending (cf. tracking my food intake), and I record in a little notebook the money I spend. But I want a way to keep it in the computer, along with the ability to filter, sort, and summarize—way beyond a text file and more things than what a spreadsheet can do. I looked for freeware home finance programs, but those are way overkill: account-oriented, investment-focused, and the like. I may get there, but I want to start simpler.
So it occurred to me that LibreOffice (né OpenOffice—name changed (apparently) with Version 3) comes with a relational database. At one time I was up to speed on that kind of thing—first, second, third, fourth normal forms, etc.—but I am rusty. I’ve found a little tutorial and it’s coming back to me, so another goal today is to create my little expenditures database. (The Wife thinks this is overkill, but the canned systems strike me as overkill.)
A shaving Buy/Sell/Trade thread I didn’t know
It turns out that Reddit has its own B/S/T thread, the Shave Bazaar.
A shave of learning
I went with The Shave Den’s Victorian Rose shave soap and aftershave, using my Semogue Owner’s Club boar brush.
You can see in the photo that the bristles don’t really clump together as a brush, but rather are gathered in an unruly sort of cowlick. This is not so bad on my now-discarded Semogue 2000, but still not a good sign—and indeed this brush as well had the splay of a chaotic knot.
Still, I was able to get a reasonable lather. I wanted to return to using The Shave Den’s preshave balm, but I decided to try applying it after my MR GLO beard wash. That didn’t work so well: the instructions to apply it before shower are better. The result of applying it late was feeling its presence somewhat catching the razor, and I don’t think it did the lather much good either. Better to do what the instructions say. (I find that is often the case, but you never know, do you?)
Once again I am struck by the comfort of the iKon head design. Three smooth passes with the Personna 74 tungsten-steel blade, followed by a splash of TSD Victorian Rose aftershave, and I’m ready for the day.
How Corzine will walk
You can already see the direction this will go: he broke no regulations, because he pressured the regulators to allow his firm an exception. So taking the customer’s money was legal. Etc. Read this for more.
The Ladykillers in two versions
I wanted to see again The Ladykillers, with Alec Guiness. But when I put it in my Netflix queue, The Ladykillers as remade by the Coen brothers with Tom Hanks was suggested, so I got that as well.
I’ve just watched the two movies back to back and found the quite interesting.
First: no contest, the classic version is simply much better: less outré and funnier and fitted more smoothly into daily life.
OTOH, I enjoyed the ingenuity of the “translation” of the movie from London to Mississippi and the various alterations made: for example, the gang continues to pretend they are amateur musicians, but in the original they met in an upstairs room and in the remake in a basement cellar (important in this case to the plot).
Instead of a wayward parrot, as in the original, we have a wayward cat.
But the original is much stronger: the group scenes work with balletic precision, and the Coen brothers cannot match Mrs. Wilberforce’s sweetness and deftness in creating instant chaos about her. The tea party scene is also infinitely stronger in the original.
Moreover—and I’d be interested in your take on this—a certain miasma of mean-spiritedness wafted from the Coen brothers’ effort. Of course, with any group of murderers you’re likely to encounter a less-than-wholesome attitude toward the world, but I found the original light-hearted and amusing while the remake is a little bit tense and white-knuckled.
Senescent cells impact aging and lifespan
Interesting finding. Tia Ghose has a brief report in The Scientist, and Nicholas Wade reports in the NY Times.
Ghose’s report:
Researchers have been able to delay the onset of age-related health declines in mice by selectively killing off aging cells, suggesting that cellular senescence can actively causing damage to surrounding tissue. The findings, published today (November 2) in Nature, could one day be used to create anti-aging therapies.
“It’s been speculated for some time that these senescent cells are a major cause of what goes wrong with aging,” said molecular and cell biologistJudith Campisi of the Buck Institute for Research on Aging in Calif., who was not involved in the study. “So this is really a very important step forward in validating that hypothesis.”
Indeed, researchers have long recognized the role of senescent cells—aging cells which no longer divide—in the health decline that accompanies aging, such as muscle weakness, heart problems, cataracts, and other ailments. But it wasn’t clear whether aging cells cause harm because they actively secrete inflammatory molecules such as cytokines, or whether they were simply dead weight, harmful because they had lost their normal cellular functions, said Norman Sharpless, a gerontologist and oncologist at the University of North Carolina at Chapel Hill, who was not involved in the study.
To answer this question, cancer biologist Jan van Deursen of the Mayo Clinic and his colleagues developed a clever test. Senescent cells, which often harbor genetic damage, secrete a tumor suppressor molecule called p16. Van Deursen and his team created mice that age prematurely, falling prey to a variety of age-related diseases early in life. They also inserted a gene into the mouse genome, which allowed them to selectively kill cells expressing p16 by feeding the mice rosiglitazone, a common diabetes drug. . .
Wade’s report:
In a potentially fundamental advance, researchers have opened up a novel approach to combating the effects of aging with the discovery that a special category of cells, known as senescent cells, are bad actors that promote the aging of the tissues. Cleansing the body of the cells, they hope, could postpone many of the diseases of aging.
The findings raise the prospect that any therapy that rids the body of senescent cells would protect it from the ravages of aging. But many more tests will be needed before scientists know if drugs can be developed to help people live longer.
Senescent cells accumulate in aging tissues, like arthritic knees, cataracts and the plaque that may line elderly arteries. The cells secrete agents that stimulate the immune system and cause low-level inflammation. Until now, there has been no way to tell if the presence of the cells is good, bad or indifferent.
The answer turns out to be that the cells hasten aging in the tissues in which they accumulate. In a delicate feat of genetic engineering, a research team led by Darren J. Baker and Jan M. van Deursen at the Mayo Clinic in Rochester, Minn., has generated a strain of mouse in which all the senescent cells can be purged by giving the mice a drug that forces the cells to self-destruct.
Rid of the senescent cells, the Mayo Clinic researchers reported online Wednesday in the journal Nature, the mice’s tissues showed . . .




