And even more: 3000 IU vitamin D daily?
Advances in Vitamin D nutritional physiology since publication of the DRIs in 1997 are briefly summarized. Available data indicate that (1) Vitamin D’s canonical function, optimizing intestinal calcium absorption, is fully expressed at serum 25-hydroxyvitamin D (25OHD) concentration of 80 nmol/L; (2) elevated parathyroid activity, typical of aging populations, is minimized at the same 25OHD value and (3) osteoporotic fractures are reduced when serum 25OHD is raised to near 80 nmol/L. Depending upon starting value, achieving 25OHD concentrations of 80 or higher may require a daily oral intake of 2200 IU (55 μg) or more in addition to prevailing cutaneous inputs. The tolerable upper intake level (TUIL), currently set at 2000 IU (50 μg)/day, is too low to permit optimization of Vitamin D status in the general population. Actual toxicity is not seen below serum 25OHD values of 250 nmol/L, a value that would be produced only at continuing oral intakes in excess of 10,000 IU (250 μg)/day.
I’m increasing my vitamin D supplement to 3000 IU daily.
Vitamin D toxicity, when it occurs, is a serious problem. The first sign is a rise in the ratio of calcium to creatinine in the urine, which precedes hypercalcemia and the problems associated with it. Yet, vitamin D toxicity is rare; its risk has been greatly exaggerated by inappropriate animal studies involving pharmacologic doses of vitamin D that have no relevance to human physiology. Heaney and associates gave people 10 000 IU of vitamin D3 daily for 5 months and did not observe a single adverse urinary calcium–creatinine event.