Later On

A blog written for those whose interests more or less match mine.

Fructose and overeating

with 2 comments

High-fructose corn syrup seems to be in everything. Could that contribute to the prevalence of obesity? Megan Brooks reports at Medscape:

Consuming fructose appears to cause changes in the brain that may lead to overeating, a new study suggests.

“Increases in fructose consumption have paralleled the increasing prevalence of obesity, and high-fructose diets are thought to promote weight gain and insulin resistance,” lead author Kathleen A. Page, MD, and colleagues from Yale University in New Haven, Connecticut, write.

In this study, they showed in healthy volunteers that although glucose ingestion resulted in reduced activation of the hypothalamus, insula, and striatum on MRI — areas that regulate appetite, motivation, and reward processing — as well as increased functional connections between the hypothalamic striatal network and increased satiety. Fructose ingestion had none of these effects.

“The disparate responses to fructose were associated with reduced systemic levels of the satiety-signaling hormone insulin and were not likely attributable to an inability of fructose to cross the blood-brain barrier into the hypothalamus or to a lack of hypothalamic expression of genes necessary for fructose metabolism,” they conclude.

Their findings are published in the January 2 issue of the Journal of the American Medical Association.

Glucose vs Fructose

Fructose ingestion produces . . .

Continue reading.

Written by LeisureGuy

2 January 2013 at 2:19 pm

Posted in Daily life, Food, Health, Science

2 Responses

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  1. This is fraudulent science. 75 grams of fructose is three times as much as people could reasonably be expected to absorb. “It appears we can absorb, at any one time, up to 25 grams of fructose. Now what is 25 grams? A glass of orange juice has up to 14 grams of fructose, a can of Coke sometimes has 15 to 16 grams of fructose (Satish Rao at University of Iowa. Ability of the normal human small intestine to absorb fructose: evaluation by breath testing. Rao SS, Attaluri A, Anderson L, Stumbo P. Clin Gastroenterol Hepatol 2007 Aug;5(8):959-563).

    So, because the fructose wasn’t even absorbed, not only did it therefore fail to “promote satiety,” it probably also gave them gas and physical discomfort. And this is how the food fascists “educate” people that “high-fructose corn syrup is bad.”

    Carol Thompson

    6 January 2013 at 11:02 am

  2. In this blog we generally eschew propagandistic terminology such as “food fascist”. Make your point on facts and leave the propaganda at home.

    Your accusation that this study, funded by the NIH and done by Yale University and reported in the (peer-reviewed) Journal of the American Medical Association is fraudulent is quite serious. You would need substantially more evidence to prove fraud, which is your claim, and including a phrase like “food fascist” casts doubt on your ability to be objective. I pretty much dismiss your comment simply from the rhetoric you employ. Sorry. A more temperate tone might be more convincing.

    Moreover, the study made no claims at all that 75g of fructose/glucose were absorbed. That was simply the quantity that was imbibed—and not diluted, as in Coke or orange juice, but undiluted (as specified in the article): 2.6 oz of glucose or fructose, or less than 1/4 c. And whether all of it was absorbed or not, the issue is what happened after ingesting the pure sugar (of each variety): that was the study.

    Really, you should calm down and read more carefully. And drop the emotional rhetoric: it makes people dismiss your writing immediately.


    6 January 2013 at 11:16 am

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