Later On

A blog written for those whose interests more or less match mine.

Your microbiome and your genetic profile

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Interesting article by Jef Akst in The Scientist:

Scouring the genomes and body-wide microbial communities of 93 people, researchers have discovered a link between the composition of the microbiome and genetic variation in innate immunity, phagocyte function, and other immune pathways. The research was presented by University of Minnesota population geneticist Ran Blekhmantoday (October 24) at the American Society of Human Genetics 2013 annual meeting in Boston.

“This is cool stuff,” Lita Proctor from the National Human Genome Research Institute wrote in an e-mail to The Scientist. “This study is the one of the first documenting the relationship between microbiome composition and the human genome.”

Other researchers have linked specific gene variants to alterations in the human microbiome, notedGeorge Weinstock of The Genome Institute at Washington University, whose own work has shown that host-microbe interactions are influenced by genes involved in drug metabolism. This study, however, may well be the first genome-wide search for such variants in humans, and “genetic variation in mouse does not represent genetic variation that segregates in human populations,” Blekhman noted.

While working as a postdoc in Andrew Clark’s lab at Cornell University, Blekhman knew that the composition of the microbiome was linked to various diseases, like diabetes, and that such diseases had also been shown to have a genetic component. So he was curious to learn how the microbiome is connected to the genes of the host.

To answer this question, he and his colleagues . . .

Continue reading.

Written by Leisureguy

25 October 2013 at 10:38 am

Posted in Health, Science

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